Abstract
Dragon fruit stem contains many organic acids, proteins, minerals such as potassium, magnesium, calcium and iron, vitamin C, and sources of antioxidants that have properties to lower blood pressure and blood sugar levels and increase immune system activity. Objective: To analyze the extract of dragon fruit stems from Pelaihari in reducing IgG levels in Pregnant Female Wistar Rats as Immunomodulator Candidates. Method: The research design used experimental. This study on test animals, mice were divided into 5 groups, namely the normal control group, negative control (injected with 10% SDMD antigen), pregnant mice were injected with 10% SDMD antigen + dragon fruit stem extract 500mg, 1000mg and 2000 mg-KgBW-day for 20 days, after which IgG were examined. blood samples were examined, TBARS test analysis, and One Way Anova test analysis. Results: There was an effect of dragon fruit extract on reducing IgG levels in pregnant mice (p<0.05). Doses of 1000mg and 2000mg dragon fruit extract have the ability to decrease IgG levels in pregnant mice, especially at a dose of 2000 mg-KgBW-day. Conclusion: Dragon Fruit plant stem extract can reduce IgG and improve the immune system in pregnant female mice
There is no Figure or data content available for this article
References
- Kamalanathan A, Padmavathy K, Sivakumari K, Karthika S, Rajesh S, Ashok K. Phytochemical Profiling and Anticancer Activity of Dragon Fruit Hylocereus Undatus Extracts Against Human Hepatocellular Carcinoma Cancer (Hepg-2) Cells. Int J Pharm Sci Res. 2021;12(5):2770-2778. doi:10.13040/IJPSR.0975-8232.12(5).2770-78
- Zain NM, Nazeri MA, Azman NA. Assessment on bioactive compounds and the effect of microwave on pitaya peel. J Teknol. 2019;81(2). doi:10.11113/jt.v81.12847
- Som AM, Ahmat N, Abdul Hamid HA, Azizuddin NM. A comparative study on foliage and peels of Hylocereus undatus (white dragon fruit) regarding their antioxidant activity and phenolic content. Heliyon. 2019;5(2). doi:10.1016/j.heliyon.2019.e01244
- Chen J. Phytochemical Cocktail – Waste Utilization of Inedible Dragon Fruit Peel. Can Sci Fair J. 2018;1(1):2-8.
- Chen Z, Zhong B, Barrow CJ, Dunshea FR, Suleria HAR. Identification of phenolic compounds in Australian grown dragon fruits by LC-ESI-QTOF-MS/MS and determination of their antioxidant potential. Arab J Chem. 2021;14(6):103151. doi:10.1016/j.arabjc.2021.103151
- Soccio M, Laus MN, Alfarano M, Dalfino G, Panunzio MF, Pastore D. Antioxidant/Oxidant Balance as a novel approach to evaluate the effect on serum of long-term intake of plant antioxidant-rich foods. J Funct Foods. 2018;40. doi:10.1016/j.jff.2017.12.012
- Reboredo-Rodríguez P, González-Barreiro C, Cancho-Grande B, et al. Characterization of phenolic extracts from Brava extra virgin olive oils and their cytotoxic effects on MCF-7 breast cancer cells. Food Chem Toxicol. 2018;119. doi:10.1016/j.fct.2018.05.026
- Tsai Y, Lin CG, Chen WL, et al. Evaluation of the antioxidant and wound-healing properties of extracts from different parts of hylocereus polyrhizus. Agronomy. 2019;9(1):1-11. doi:10.3390/agronomy9010027
- Niah R, Helda. Aktivitas Antioksidan Ekstrak Etanol Kulit Buah Naga Merah Daerah Pelaihari, Kalimantan Selatan Dengan Metode DPPH (2,2-difenil-1-pikrilhidrazil). J Pharmascience. 2016;03(02).
- Ari Sri Windyaswari, Fahrauk Faramayuda DR. Brine shrimp lethality test. Kartika J Ilm Farm. 2015;3(1):36-42.
- Fihiruddin, Artama WT, Wibawa T, Mertaniasih NM. Expression of immunoglobulin, granzyme-B and perforin against Ag85A and Ag85B proteins of mycobacterium tuberculosis in Balb/c mice. African J Infect Dis. 2019;13(2). doi:10.21010/ajid.v13i2.2
- Kumar A, Abrol E, Koul S, Vyas D. Seasonal low temperature plays an important role in increasing metabolic content of secondary metabolites in Withania somnifera (L.) Dunal and affects the time of harvesting. Acta Physiol Plant. 2012;34(5). doi:10.1007/s11738-012-0968-0
- Wahdaningsih S, Wahyuono S, Riyanto S, Murwanti R. In vitro test of macrophage phagocytic activity of extracts and fractions of red dragon fruit peel [Hylocereus polyrhizus (F.A.C.Weber) Britton and Rose]. Dhaka Univ J Pharm Sci. 2018;17(2). doi:10.3329/dujps.v17i2.39171
- Eka Y HHW. Effect of Hylocereus Polyrhizus Rind Extract Toward Interleukin-1?.pdf. Published online 2017:617-621. doi:10.25258/ijpcr.v9i08.9588
- Maigoda TC, Sulaeman A, Setiawan B, Wibawan WT. Effects of Red Dragon Fruits (Hylocereus polyrhizus) Powder and Swimming Exercise on Inflammation, Oxidative Stress Markers, and Physical Fitness in Male Obesity Rats (Sprague dawley). Int J Sci Basic Appl Res. 2016;25(1).
- K H, R J. In-vitro immunomodulatory activity of dragon fruit extract. Int J Pharma Bio Sci. 2019;10(3). doi:10.22376/ijpbs.2019.10.3.b99-106
- Sangkuanun T, Wichienchot S, Kato Y, Watanabe H, Peerakietkhajorn S. Oligosaccharides derived from dragon fruit modulate gut microbiota, reduce oxidative stress and stimulate toll-pathway related gene expression in freshwater crustacean Daphnia magna. Fish Shellfish Immunol. 2020;103. doi:10.1016/j.fsi.2020.04.046
- Kadek Febriyanti, Ni Putu Eka Leliqia. Review: Studi Kandungan Fitokimia dan Aktivitas Antibakteri Tanaman Buah Naga (Hylocereus spp.). Pros Work dan Semin Nas Farm. 2023;2. doi:10.24843/wsnf.2022.v02.p09
- Sulistyarini I, Sari DA, Wicaksono TA. Skrining Fitokimia Senyawa Metabolit Sekunder Batang Buah Naga (Hylocereus polyrhizus). J Ilm Cendekia Eksakta. Published online 2019:56-62.
- Wientarsih I, Prasetyo BF, Kurniawan A, Hanifah F. Study On Antioxidant Activity Bisbul Pulp And Red Dragon Fruit Stem By Using 1,1-Diphenyl-2-Picrylhydrazin Method. J Vet. 2020;21(4). doi:10.19087/jveteriner.2020.21.4.596
- Bassiag SKR, Aguinaldo KR, Singson ZA, Guzmán R. Phytochemical Analysis of Dragon Fruit (Hylocereus Spp.) and Carica Papaya Stems. Res Sq. Published online 2023.
How to Cite This
Article Metrics
Download Statistics
Other Statistics
Copyright and Permissions
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.