Suplementation of iron assosiated with increasing cholesterol levels in pregnant women
Abstract
Iron supplementation is the most broadly utilized way to deal with controlling the worldwide issue of iron lack paleness. This study aimed to prove the effect of iron supplementation on cholesterol levels of pregnant women. This study was experimental study which type was 3 groups with the post-test only design was employed to determine the cholesterol level in pregnant women. The sample was the pregnant women in Kepuharjo Village, Yogyakarta, Indonesia who intake iron supplements. It’s classified the intervention into 3 groups as no iron supplement use, iron supplement use ? 90 tablets and iron supplement use > 90 tablets. Each group included 30 pregnant women who fulfilled the inclusion and exclusion criteria. Cholesterol level were presented with mean and standard deviation. ANOVA with LSD were performed to compare cholesterol level from all groups to the respective iron supplement group. The results revealed that cholesterol level among no iron supplement use, iron supplement use ? 90 tablets and iron supplement use > 90 tablets were 152.53 (SD 34.67), 175.53 (SD 34.67) and 239.50 (SD 41.27), respectively. There was a significant difference among the mean cholesterol level on three groups. The post-hoc test showed the group of iron supplement use less than equal to 90 tablets and the group of iron supplement use > 90 tablets differed statistically significantly in term of their cholesterol level. Optimum iron supplement dosage should be considered for pregnant women.
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References
- Development Initiatives. (2018). Global Nutrition Report: Shining a light to spur action on nutrition. Bristol, UK: Development Initiatives.
- Chaparro, C., Oot, L., and Sethuraman, K.. (2014). Overview of the Nutrition Situation in Seven Countries in Southeast Asia.. Washington, DC: FHI 360/FANTA.
- Young, F.M.. (2018). Maternal Anaemia and risk of mortality: a call for action. The Lancet, Global Health.; 6(5): E479-E480.
- Patel A, Prakash AA, Das PK, Gupta S, Pusdekar YV, & Hibberd LP. (2018). Maternal anemia and underweight as determinants of pregnancy outcomes: cohort study in eastern rural Maharashtra, India. BMJ Open, 8(8), e021623.
- Cunningham FG., Leveno, K.J., Hauth, J.C., Rouse, D.J., Spong, C.Y.. (2012). William Obstetrics, 23rd, Penterjemah; Brahm U. Pendit; Setia R (Editor). (). Jakarta : Penerbit Buku Kedokteran EGC, McGraw-Hill Companies, New York.
- Hinderaker S.G., Olsen B.E., Lie R.T., Bergsjø, P.B., Gasheka, P., Bondevik, G.T. Ulvik R. and Kvåle, K.. (2002). Anemia in pregnancy in rural Tanzania: associations with micronutrients status and infections, European Journal of Clinical Nutrition, 2002, 56(3), 192-199.
- Ahmed, F., Khan, M.R. and Jackson, A.A.. (2007) Concomitant Supplemental Vitamin A Enhances the Response to Weekly Supplemental Iron and Folic Acid in Anemic Teenagers In Urban Bangladesh. American Journal Clinical Nutriton, 74(1), 108-115.
- Figueiredo, A.C.M.G., Gomes-Filho, I.S., Batista, J.E.T., Orrico, G.S., Porto, E.C.L., Pimenta, R.M.C., Conceição, S.D.S., Brito, S.M., Ramos, M.D.S.X., Sena, M.C.F., Vilasboas, S.W.S.L., Cruz, S.S.D., and Pereira, M.G.. (2019). Maternal Anemia and birth weight: A prospective cohort study, PloS ONE, 14(3), e0212817.
- World Health Organization. (2016). WHO recommendations on antenatal care for a positive pregnancy experience. Luxembourg: WHO Press.
- Kodyat, B., Kosen, S., and De, P.S.. (1998). Iron deficiency in Indonesia: current situation and intervention. Nutrition Research, 18(12), 1953–63.
- Casanueva, E., and Viteri, F.E.. (2003). Iron and oxidative Stress in Pregnancy. Journal of Nutrient, 133(5), 1700s-1708s.
- Stolzfus, R.J., and Drreyfuss, M.L., editors. (1998). Guidelines for the use of iron supplementation to prevent and treat iron deficiency anemia. Washington DC: ILSI Press.
- Javadian, P., Alimohamadi, S., Gharedaghi, M.H., and Hantoushzadeh S.. (2014). Gestational diabetes mellitus and iron supplement; effects on pregnancy outcome. Acta Medica Iranica Journal, 52(5), 385-389
- Duki?, A., Zivancevi?-Simonovi?, S., Varjaci?, M., and Duki?, S.. (2009). Hyperlipidemia and pregnancy. Medicinski pregled, 62(Suppl 3), 80-84.
- De Assis, S.M.A., Seguro, A.C., and Helou, C.M.B.. (2003). Effects of maternal hypercholesterolemia on pregnancy and development of offspring. Pediatric Nephrology, 18(4), 328-334.
- Montoudis, A., Simoneau, L., Brissette, L., Forest, J.C., Savard, R., and Lafond, J.. (1999). Impact of a cholesterol enriched diet on maternal and fetal plasma lipids and fetal deposition in pregnant rabbits. Life Sciences, 64(26), 2439-50.
- Sullivan, J.L.(1992). Stored iron and ischemic heart disease: empirical support for a new paradigm. Circulation, 86(3), 1036–1037.
- Choi JW, Kim SK, Pai SH. Changes in Serum Lipid Concentrations during Iron Depletion and after Iron Supplementation. Ann Clin Lab Sci 2001; 31: 151- 156.
- Choi JW, Pai SH. Serum lipid concentrations change with serum alkaline phosphatase activity during pregnancy. Ann Clin Lab Sci 2000; 30(4): 422-8.
- Turbino-Ribeiro,SML.,Silva,ME.,Chianca,DA.,Debert de Paula, Cardosa,LM., Colombari,E., Pedrosa,ML.2003. Iron Overload In Hypercholesterolemia Rats Effects Iron Homeostatis And Serum Lipids But Not Blood Pressure. Journal Of Nutrition. Vol 133 (1):15-20.
- Tiwari, AKM.,Mahdi, AA.,Mishra,S.2016. Effect of Iron Supplementation on Plasma Lipid Levels in Pregnant Anemic Women. International Journal of Science and Research. ISSN (Online): 2319-7064.
- Aziz R, Mahboob T. Pre-eclampsia and lipid profile. Pak J Med Sci 2007; 23: 751-754.
- Habbel RP, Eaton JW, Balasingam M, Steinberg MH. Spontaneous oxygen radical generation by sickle erythrocytes. J Clin Invest 1982; 70: 1253-1259.
- Aslan M, Thornley-Brown D, Freeman BA. Reactive species in sickle cell disease. Ann N Y Acad Sci 2000; 899: 375-391.
- Norum KR, Gjone E. Familial plasma lecithin acyl transferase deficiency. Biochemical study of a new inborn error of metabolism. Scand J Clin Lab Invest 1967; 20: 231-235.
- Zailaie MZ, Marzouki ZM, Khoja SM. Plasma and red blood cells membrane lipid concentration of sickle cell disease patients. Saudi Med J 2003; 24: 376-379.
- Choi JW, Kim SK, Pai SH. Changes in Serum Lipid Concentrations during Iron Depletion and after Iron Supplementation. Ann Clin Lab Sci 2001; 31: 151- 156.
- Cunnane SC, McAdoo KR. Iron intake influences essential fatty acid and lipid composition of rat plasma and erythrocytes. J Nutr 1987; 117: 1514-1519.
- Ohira Y, Edgerton VR, Gardner GW, Senewiratne B. Serum lipid levels in iron deficiency anemia and effects of various treatments. J Nutr Sci Vitaminol 1980; 26: 375-379.
- Steinberg D. Lewis A. Conner Memorial Lecture. Oxidative modification of. LDL and atherogenesis. Circulation 1997; 95: 1062-1071.
- McCord JM. Effects of positive iron status at a cellular level. Nutr Rev 1996; 54: 85-88.
- Salonen, JT, Nyyssonen K, Korpela H, Tuomilehto J, Seppanen R, Salonen R. High stored iron levels are associated with excess risk of myocardial infarction in eastern Finnish men. Circulation 1992; 86: 803-811.
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