MODEL PREDIKSI FUNGSI TIROID BERDASARKAN FAKTOR UMUR DAN KADAR PLUMBUM (Pb) DALAM DARAH

Abstract

Recently, there were many reports a occurence of iodine deficiency disorders (/DD) and extension of goitre area in lowlands urban which should be enough of iodine. Air pollution caused by motor-vehicle has reached high level in urban area (60-70%). Research in Yogyakarta (1997) found 55,9% subject was contaminated by plumbum. Another research found there were mothers with low iodine status. It is expected other factors were inhibiting iodine utilization process. The child bearing age women (CSA W) are among vulnerable group when incured lead exposure. It is related to possible hazard to their pregnancy and foetus. The aim of this study was to find prediction model the thyroid function based on age and blood lead level factors among CBAW with risk of plumbum exposure in urban area. Study design was cross-sectional. This study conducted in crowded traffic area in Yogyakarta. Subject were 99 CBAW 15-49 year. Blood lead level was analyzed by AAS method; TSH-FT4 by ELISA; U/E by APDM; haemoglobin by CyanmetHb; data of cyanide and protein intake were collected by interview using Semi-FFQ; and nutritional status was determined by BM/. Proportion of hypothyroidism was 19,2% (95%Cl: 11,4%-26,9%). The CBAW with high blood lead level was 49,5%. Logistic regression test result showed there was relationship between blood lead level with thyroid function (p=0,018, RR=3,99). The contribution of age was very small (p=0,031, RR=0,92). The t test result showed there was no relationship between cyanide, protein and iodine consumtion, haemoglobin level, and nutrition status with thyroid function. The high blood lead level was the risk factor of hypothyroidism among CBAW with risk of plumbum (Pb) exposure in urban area.